![]() ![]() It also comes with a dock that connects to a countertop POS for storefront use. This is helpful because you can bring your own devices. ![]() The Helcim card reader connects to your smartphone, tablet, or computer, along with Helcim’s payments app, to create a fully functional POS system. It holistically integrates with your Helcim account to centralize all your data. The Helcim card reader costs $109 per unit and allows merchants to accept swipe, chip, tap, and keyed-in card payments. Helcim users who signed up after June 2020 will be using Helcim’s new card reader instead of getting integrated Ingenico and Poynt smart terminals. *Helcim’s acquiring bank charges extra for accessing the Amex network and are added to Helcim’s transaction rates. American Express surcharge fees*: 0.10% + 10 cents per transaction.Domestic ACH/Wire Transfers: 0.5% + 25 cents, $5 return fee.Most providers that offer free merchant accounts are payment facilitators or payment service providers (PSPs) like Square and Stripe.Īccording to Helcim, the average processing fee for card-present transactions is 1.94% + 8 cents, while the average processing fee for card-not-present transactions is 2.51% + 25 cents. Its automated discount, interchange-plus pricing model comes with no monthly fee for a dedicated merchant account, which is a rare find. Helcim offers a fairly extensive set of tools for businesses of all sizes, spanning a wide range of industries for a very competitive price. For occasional sellers: Consider a mobile point-of-sale (POS) or payment app like Square or PayPal.For high-risk businesses: Check out one of these best high-risk merchant accounts for small businesses.For high-volume sales: Automatic volume discounts when processing over $25,000 monthly in sales.For retailers: Free ecommerce and POS tools make Helcim an ideal payment processor for retailers.For free merchant services: Zero monthly fees make Helcim one of the best free merchant accounts in the market.For low-cost payment processing: Offers one of the cheapest credit card processors for small businesses.
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‘TGF-beta3 protects normal human hematopoietic progenitor cells treated with 4-hydroperoxycyclophosphamide in vitro’. Lemoli, R.M., Strife, A., Clarkson, B.D., Haley, J.D. ‘The effects of TGF-beta3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood’. Strife, A., Lambek, C., Perez, A., Darzynkiewicz, Z., Skierski, J., Gulati, S., Haley, J.D., ten Dijke, P., Iwata, K. ‘Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis’. ‘Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors’. (1987) ‘Porcine relaxin: Gene structure and expression’. Haley, J., Crawford, W., Hudson, P., Scanlon, D., Tregear, G., Shine, J. (1983) ‘Structure of a genomic clone encoding biologically active human relaxin’ Nature 30l, 628-631. Hudson, P., Haley, J., John, M., Cronk, M., Crawford, R., Haralambidis, J., Tregear, G., Shine, J., and Niall, H. (1982) ‘Porcine relaxin: Molecular cloning and cDNA structure’ DNA 1, 155-162. Haley, J., Hudson, H., Scanlon, D., John, M., Cronk, M., Shine, J., Tregear, G., and Niall, H. (1981) ‘Molecular cloning and characterization of cDNA sequences coding for rat relaxin’ Nature 291, 127-131. Hudson, P., Haley, J., Cronk, M., Shine, J. Through his experience in the Pharmaceutical industry, he is seeking to foster partnerships with peer institutions and with biotechnology and pharmaceutical companies, with the vision of developing novel approaches to cancer therapies at Stony Brook Medicine. He has presented numerous research seminars at national meetings, and he has served on a number of NCI grant review study sections. Haley holds numerous patents and has authored over 60 manuscripts related to the development of novel cancer therapeutics. He has published on the exploration of cancer drug resistance and cancer biomarkers, and has organized and chaired several AACR symposia and mini-symposia on the subject. He has a strong interest in drug discovery and development, most recently in Translational Medicine and Pharmacogenomics at OSI Pharmaceuticals, using biological mass spectrometry as a research tool for the quantitation of signaling networks. Haley served as Senior Director for Exploratory Cancer Research, Senior Research Director for Translational and EMT Research, and Senior Research Director for Discovery Research. as Program Manager for Cancer Therapeutics and was subsequently recruited to OSI Pharmaceutical Inc. in Molecular Endocrinology from the Howard Florey Institute for Experimental Physiology and the University of Melbourne and completed postdoctoral research fellowships at the Howard Florey Institute in Melbourne and at the Imperial Cancer Research Fund and the Ludwig Institute for Cancer Research in London. Haley earned a BA in Chemistry from Tufts University and a Ph.D. Current research interests include defining and exploiting mechanisms for overcoming anti-cancer drug resistance and cancer metastasis.ĭr. Through the generation and molecular characterization of EMT models, through RNAi-based target validation studies and follow-on pharmacology studies, new targets and compounds which promote death of metastatic cells can be identified and validated in panels of cell lines. New therapeutics are needed to target the new spectrum of tumor survival signals now present within EMT-derived cells and within related cancer-stem cells. ![]() ![]() EMT is an important cellular change which allows for metastasis and is associated with poor prognosis and resistance to chemo and targeted therapies in cancer patients. Several forms of plasticity have been documented, including epithelial mesenchymal transition (EMT), endothelial-mesenchymal transition and epithelial-neuroendocrine transition. Cellular plasticity plays a major role in the progression of cancer and the acquisition of mesenchymal cancer stem cell-like phenotypes has been correlated with poor prognosis. ![]() It is clear that metastatic cancers are increasingly heterogeneous, that is many different cell types and states are present within cancer tissues, and importantly metastatic cancers show increased resistance to radiation, chemotherapies and targeted therapies. Over 90% of cancer patient deaths are attributable to metastasis and the majority of patients treated in Phase I and Phase II clinical trials have metastatic cancers. Associate Professor of Research, Department of Pathologyĭirector, Developmental Therapeutics, SBU Cancer Center Keep in mind that dosages are not the same for pets as for people! Your vet can guide you in the appropriate dosing of these products. Antihistamines like diphenhydramine and cetirizine are safe for dogs as long as they don’t contain any decongestants. Common symptoms in dogs are sneezing, a mild, clear eye discharge, and itching. Our dogs are just as prone to having allergies as we are. If your dog’s itchy skin is more severe, your vet may recommend an antiseptic shampoo or mousse product with an ingredient like chlorhexidine. ![]() ![]() Look for products that are oatmeal-based and fragrance-free for best results. There are many over-the-counter shampoos available for dogs with dry, itchy skin. Never bandage a hot spot, as this will delay the healing process and can lead to further complications. Severe hot spots (ones that don’t improve in 24–48 hours) may require oral antibiotics and anti-inflammatories from your vet. Some dogs may be in too much pain to allow their pet parent to trim the hair. If you and your dog are comfortable with shaving the fur around the lesion with electric clippers (never scissors!) to get more air exposure, this can also help. The most important thing to remember in treating a hot spot is keeping your dog from licking or scratching at it.Įlizabethan collars (e-collars) and loose T-shirts or shorts are highly effective at protecting these lesions as they heal. Hot spots can be seen in any breed, but they are most common in dogs with thick coats like Golden Retrievers and German Shepherds. Hot spots are localized areas of inflammation in the skin that erupt suddenly and cause discomfort and frequent licking or scratching, which makes the lesion worse. Dogs that have blood in the stool, decreased appetite, or vomiting should also be promptly evaluated by a veterinarian to ensure there isn’t a more serious cause. If your dog’s diarrhea is not decreasing during that time, a call to the vet is warranted to see if a prescription diet or probiotics may be needed. It is important not to roast or fry the meat, as the meat fat can cause pancreatitis.Ī bland diet should not be fed for more than a week in adult dogs and two to three days in growing puppies. A bland diet at home is usually a combination of boiled chicken, turkey, or beef and rice. ![]() Dogs with soft stool that are otherwise eating well and acting normally can be temporarily given a bland, easily digestible diet to allow the intestines some time to rest and heal from the inflammation causing the diarrhea. Mild Diarrhea/Mucus in StoolĪ short course of mild diarrhea doesn’t always mean a trip to the vet. 8 Conditions That Can Benefit From Home Remedies for Dogs 1. While reaching out to your veterinarian for advice or an appointment is always recommended, there are some nonprescription therapies that are usually safe to try at home before you call or while you wait for an appointment. Sometimes issues come up at the most inconvenient times. Being a pet parent means being prepared for the unexpected. ![]() As the summer progresses and food becomes scarce, moose may venture into more open areas in search of sustenance. Behavior in Summer and Winterĭuring the summer months, moose are most active in the early morning and late evening, spending much of the day resting in cool, shaded areas. In contrast, the tail of a moose is small and stubby, adding to its overall appearance of immense size and power. The antlers of bull moose are a distinctive feature, growing up to six and a half feet across. The fur can range in color from black to dark brown, gray-brown, or red-brown on the upper parts of the body, while the legs and other lower parts are usually lighter in color, with gray-brown or almost white fur.ĭuring the winter, the fur coat becomes even thicker, providing ample protection against the cold. ![]() Moose have a thick, warm fur coat that is made up of hollow hairs ranging from 6″ to 10″ (15 to 25 centimeters) in length. The head of a moose is large and rotatable, with huge ears that can pivot 180 degrees. The deep and muscular shoulders of a moose give the appearance of a hump at the base of the neck, but in reality, the neck of a moose is short and stocky. They have large, even-toed hooves that serve as snowshoes in the winter and on muddy ground. Standing taller than the largest saddle horse at the shoulder, these animals are massive and heavily built, with long and thin legs that are longer in the front than in the back. They are truly something to behold due to their towering height and powerful build. The moose is a majestic and imposing creature renowned for its towering size and striking appearance. The word has become a part of standard English and is used as both singular and plural, such as one moose or a herd of moose. “Moose” is a loan word, meaning it was borrowed from Native American languages in the early 1600s and incorporated into the English language with little or no modification. The plural of “moose” is simply “moose” and not “meese,” as some might think. The word was adopted by European settlers in North America and has been used to refer to the large, herbivorous mammal known for its distinctive antlers. The word “moose” comes from the Algonquian word “moosu,” which means “twig eater.” The Algonquian language was spoken by several indigenous tribes in North America, including the Abenaki, Ojibwe, and Cree. These magnificent creatures are known for their distinctive appearance, including their tall stature, black coloration, long legs, pendulous muzzle, and hairy dewlap, known as a bell (the skin under their neck). The moose is the largest member of the deer family Cervidae and belongs to the order Artiodactyla. And we’ll give you a glimpse into what the future of moose conservation might look like. The goal of this article is to show you how important moose are, not just for the environment but also for human culture. ![]() We’ll dive into what’s causing their decline and the efforts being made to protect them. In this article, we’re going to talk about moose and the current state of their populations. Unfortunately, things like habitat loss, disease, and conflicts with humans are making it harder for them to survive. Moose are found all over the northern parts of the world and play a huge role in their ecosystems. Have you ever seen a moose in the wild? These giant deer are incredible creatures, but did you know that moose populations are facing some serious challenges these days? ![]() 10-Find events to attend, whether virtual or local. And that’s where you’ll find the best active gurus, too. It’s the place with the most technically oriented discussions. Join LinkedIn groups as well, but the forum comes first. Here’s some advice for getting the most out of the forum. There are a lot of wonderful users on the forum who are happy to help. ![]() Ask questions, and then when you can, answer them too. Perhaps the best thing you can do to learn Archicad is make the Archicad-Talk Forum your most visited website. 9-Read threads, ask questions, and answer questions on the Archicad -Talk Forum Knowing where to look for help, tutorials, add-ons, Objects, etc. I need to devote an afternoon to updating it, but it has a big list of general resources. 8-Understand that there is a ton of Archicad content available on the internet Don’t waste your energy working without a template. Using Archicad without a good template can be such a mess. A good template will not only make using Archicad easier, it’ll help you understand an expert’s logic. GRAPHISOFT North America has full time staff that will do training as well, and if you ask around the community there are plenty of experienced users who will be happy to assist you. Myself and others have successfully trained coworkers, other local users, and even users 100% remotely via all the great free video conferencing software out there. Money spent on training is a great investment. Some people can teach themselves Archicad. Make sure to thank them (via money, dinner, good vibes, networking, or something). ![]() Having a go-to person to answer your questions will make your life easy. This person could be in your firm, in your city, or on the Internet. You’re not necessarily looking to have them train you it’s just nice to be surrounded by other Archicad users while you learn. Chat with them, see if you can co-locate for awhile. There are most definitely other local users. 4-If you don’t have coworkers who know Archicad, search out other local users. I caught so many things that no one would have ever told me about, because the person doing the commands was doing them unconsciously. I did this when I first started using Archicad. It’s the next best thing to… 3-Watch over a coworker’s shoulder while he or she works. Videos are great because you get to watch someone work. Here’s a few Channels you should check out, but the list is always expanding and changing, so make sure to search around YouTube for more. Remember your first project isn’t going to take advantage of every aspect of Archicad. Show it to an Archicad expert and ask if they think it’d be a good one to start with. When choosing your first project, go with something comfortable and known. I once had a boss decide that a coworker’s first Archicad project would be one with a super complex roof where all the columns were multi-trunked trees that the timber framer found while walking through the forest. And if the project can be on the less complex end of your standard work, that’s even better. If you do tenant build-outs, it should be one of those, not the pro-Bono work you agreed to do for a former client. If you do houses, it should be a house, not the random dentist’s office someone asked you to design. The project should be a typical project for your firm. Which brings me to the second aspect of this piece of advice: choose your first live project wisely. Equally important, if you are recreating a project that is prototypical for your office, you’ll be learning how to do the things you’ll need to do in the future. You therefore get to focus on how to work within Archicad. What’s great about this is that you aren’t thinking about the design or the details. To learn Archicad, I highly recommend taking an old project and redoing it in Archicad. So in an effort to save everyone some time, here’s a list of things you should do if you want to learn Archicad (after of course going to and downloading a trial version for free, if you don’t already own Archicad): 1-Pick a good first project. But I don’t remember everything I’ve written, and I don’t expect you to either. If you’ve read all seven hundred(ish) blog posts and articles that I’ve written since 2010 (this is number one hundred and one on BIM Engine in case you were wondering), you’ve probably come across much of this advice. And because I am who I am, I often drop everything I’m doing and respond, whether I’m asked via the Internet, over the phone, or in person. This article was created by Jared Banks “I want to learn Archicad…what should I do?” The crowd for day two of the festival was even bigger than the first day. Reznor tore through some of his most significant hit songs and new material including Wish, March of the Pigs, and Something I Can Never Have. The massive show at Aftershock featured blinding lights, immense fog machines, and an enormous sound system, blaring the extreme noise across the park. Reznor has drawn on many talents to produce the sounds of NIN. The current incarnation of the group is one of the most intense and melodic at the same time, from the many lineups that Reznor has organized over the years. Since 1988 Trent Reznor has brought his dark vision of hardcore industrial metal music to life. The first day ended with a dramatic evening set by one of the most intense hardcore bands in music Nine Inch Nails. Guitarist James Iha and drummer Jeff Friedl round out the alternative metal powerhouse. As usual, the enigmatic lead singer Maynard Keenan, lingered mostly in the shadows in the back of the stage, while guitarist Billy Howerdel and bassist Matt McJunkins maniacally raced about the front of the stage. The band played the hit songs that have made them so famous like Stay Gold and Legend Has It.Īs evening fell and temperatures cooled to jacket weather, A Perfect Circle exploded to life in a cacophony of moody metal sound and stroking backlight. The fiesta rappers, Killer Mike and El-P, drew a huge crowd. The band have become music festival veterans and always deliver a robust set.Īs the sun dipped below the horizon and the park was painted in a beautiful orange afterglow, the music switched to Hip Hop as Run The Jewels took the stage. Georgia based heavy metal rockers Mastodon also played a blistering mid-afternoon set. Drummer Mario Duplantier showed the audience why he deserved the Loudwire award as the best Heavy metal drummer of the year. The sweaty crowd screamed their approval as the band played some of their most intense songs including, Flying Whales and Only Pain. Gojira brought their French version of hardcore heavy metal to the stage next in a blaring afternoon sun. The desert rockers opened their set with a blistering version of Magic with a guest appearance by Mastodon guitarist Brent Hinds. Lead singer and guitarist Jesse Hughes rode onstage on a tiny bicycle to kick things off. “The Eagles of Death Metal” played an emotionally inspiring show, endearing themselves to the crowd early on. The crowd on the first day was most older adult music fans, probably due to a line up with veteran alternative metal bands like “Nine Inch Nails” and “A Perfect Circle.” The crowd loved the performance surging towards the stage. Hawkins had a giant hydraulic drum kit that he would ride, like a contraption from a mad max movie. ![]() “Nothing More” brought their high energy show to an already burgeoning crowd, fronted by Jonny Hawkins on lead vocals and additional percussions. By early afternoon on the first day, Heavy metal hitmakers were already performing on the main stages. The festival grounds also featured dozens of food and beverage stands, gourmet food trucks, and artisan stalls. This year’s festival featured a massive two-day lineup, headlined by Nine Inch Nails and Ozzy Osbourne, on two massive main stages and one smaller one. The event takes place in the beautiful tree lines Discovery Park on the edge of the Sacramento River.Īftershock began as a single day festival, with a modest main stage headlined by the Stone Temple Pilots with Scott Weiland and a tiny second platform, with relatively unknown bands at the time like the Hollywood Undead. The cold front gave way to nearly perfect weather for the two-day festival, with warm sunny days and cool nights prevailing. A cold front moved through the region days before the event began, blowing away the smokey skies that had engulfed Sacramento from the devastating fires in the nearby wine country. ![]() Some of the biggest names in Heavy Metal music brought 50,000 people to the sixth annual Aftershock Music Festival in Sacramento. Learn more about traveling to Portland and discover all the exciting things this city has to offer. If someone were to drive from Portland across America, it would take approximately 41 hours. Some of the neighboring cities include Vancouver, Beaverton, and Gresham. The neighboring states of Washington and California are respectively 173 miles and 634 miles away from Portland. The city is approximately 51 miles away from the nearest timezone border, which is the Mountain Time Zone. It is situated in the state of Oregon, in the Pacific Time Zone (UTC-8). Portland is a vibrant city located in the Pacific Northwest region of the United States. Depending on which season youre travelling in, you. Unique traditions/events: Portland International Film Festival, Holiday Ale Festival, ZooLights Chicago, in the Central time zone, is two hours ahead of Portland, so youll lose two hours during travel.Climate: Rainy with occasional snow and ice.Unique traditions/events: Portland Marathon, Portland Film Festival, Feast Portland.Unique traditions/events: Oregon Brewers Festival, Waterfront Blues Festival, Portland Saturday Market.Home Page Newsletter About Us Contact Us. The numbers of hours difference between the time zones. Climate: Warm and dry with occasional heat waves Time zone difference or offset between the local current time in USA Oregon Portland and USA Illinois Chicago. ![]() Unique traditions/events: Portland Rose Festival, Portland Farmers Market, Portland Dining Month.Climate: Rainy with occasional sunny days. ![]() Additionally, Portland is within driving distance of popular tourist destinations like Crater Lake National Park and the Oregon Coast. Portland is known for its vibrant nighlight compared to the rest of Oregon, as well as its proximity to outdoor recreation areas like Mount Hood and the Columbia River Gorge. Alternatively, you can also try loading the same page from another browser. ![]() ![]() Close and reopen the browser, then reload the web page.If a website is displaying a 504 Gateway Time Out error, there are a number of actions that can help resolve the problem as quickly as possible: Ways to solve the 504 error problem for the website administrator Let's look at what are the ways of solving the problem. Disabled JavaScript or cache errors can also provoke a 504 response code. Miners, Trojans and other threats can significantly increase the load on the server, thereby provoking the server response time. Injection of malicious code into site files.Not all hosters offer unlimited traffic to their customers, and in the case of overspending the available capacity is severely underestimated, resulting in a noticeable decrease in server performance. Overspending on the limits of the hosting plan.If any of them fails to load within the specified time, it will also cause an error. To fully load the site page requires that all the scripts are loaded. Some plugins download data from third-party sources, and if the requested server is unavailable, visitors will get a 504 error. Or there can be "crooked" plugins that don't work properly. When a large number of plugins and extensions are installed on the server, some of them can conflict with each other. In addition to the load, there may be other reasons for the appearance of 504 Gateway Time Out: In this case, it is recommended to migrate the site to a more powerful dedicated server or VPS with more RAM and more powerful processor cores. The most common scenario is an excessive workload on the server, which prevents it from processing all incoming requests in a timely manner. DDoS-attacks or natural overflow of visitors may provoke an error if the current configuration of the server can not cope with the load. In any case this error indicates the same problems. ![]() The variant of the text will depend on the web-server in use. In this article, we will tell you what the possible causes of error 504 and what solutions can be found. It occurs if the server does not receive a response after a set period of time – because of this, it can not load the requested page. If you see this code on the screen, it means that the waiting time limit has been exceeded due to technical problems. When trying to load a web page the server may display a 504 Gateway Time Out error. They range from a massive Terraformer (described as a “king-of-the-hill” type location that can comfortably accommodate four teams) to a “Perpetual Core” power station, whose turbine airflow can quickly get fighters out of an ambush, Shaw said. “We really wanted to give squads a chance to go to that POI but get a little more comfortable,” Shaw said.Īll 14 of Broken Moon’s POIs are explained in further detail in a blog post Respawn published on Monday. Shaw called the usual POI scrum a “hot-drop dogpile,” that eliminates a bunch of players straight away. Developing larger landmarks for players to explore means they won’t all be landing in the same spot and struggling to eliminate one another, instead of enjoying the scenery and getting familiar with the battlefield. The points of interest themselves are also an attempt to shake the cadence of a typical Apex Legends battle royale match, Shaw said. “This system’s interconnectedness really helps change your squad’s trajectory from your starting POI,” he emphasized, “so it doesn’t always feel the same, match-to-match. ![]() While Zip Rails will be greatly useful for outrunning a shrinking ring, Shaw and his colleagues hope it will introduce players to more of Broken Moon before that begins. The Zip Rail system “allows you and your squad to rotate really large distances quickly, and even hit up multiple edge POIs early, at the beginning of the game.” “We found that, generally, squads land on the outer POIs, or ‘edge POIs’, and move toward the center, on a really common trajectory from that starting POI,” Shaw said. Shaw said the Zip Rails were introduced to “shake up the traditional flow or feeling of a match,” that designers were observing into the game’s fourth year. Players can fast-travel among Broken Moon’s POIs with Zip Rails, a map feature that works like the existing Ziplines, just on a larger scale. ![]() Players will find 14 large points of interest on Broken Moon, each suitable for an intense and decisive firefight, he said. “We felt like that scale really provides a strong baseline for the pacing and feel of the game and the player count,” Shaw said in a media briefing last week. Shaw said Broken Moon is “roughly the scale” of, if not slightly larger than, World’s Edge, the huge battle royale map that dates to season 3. ![]() Image: Respawn Entertainment/Electronic Arts ![]() Get up to 5 simultaneous connections across all your devices. VPN Unlimited: Top VPN Proxy software for Windows to Protect your Privacy! VPN: An easy-to-use VPN software that focuses on user privacy and offers a large server network. VeePN: A premium VPN service known for its fast speeds and robust encryption. 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